IDDI: integrated domain-domain interaction and protein interaction analysis system
نویسندگان
چکیده
منابع مشابه
Protein Interaction Networks: Protein Domain Interaction and Protein Function Prediction
Most of a cell’s functional processes involve interactions among proteins, and a key challenge in proteomics is to better understand these complex interaction graphs at a systems level. Because of their importance in development and disease, protein-protein interactions (PPIs) have been the subject of intense research in recent years. In addition, a greater understanding of PPIs can be achieved...
متن کاملDomain-Domain Interactions Underlying Herpesvirus-Human Protein-Protein Interaction Networks
Protein-domains play an important role in mediating protein-protein interactions. Furthermore, the same domain-pairs mediate different interactions in different contexts and in various organisms, and therefore domain-pairs are considered as the building blocks of interactome networks. Here we extend these principles to the host-virus interface and find the domain-pairs that potentially mediate ...
متن کاملComparative analysis and unification of domain-domain interaction networks
MOTIVATION Certain protein domains are known to preferentially interact with other domains. Several approaches have been proposed to predict domain-domain interactions, and over nine datasets are available. Our aim is to analyse the coverage and quality of the existing resources, as well as the extent of their overlap. With this knowledge, we have the opportunity to merge individual domain inte...
متن کاملProtein interaction network based prediction of domain- domain and domain-peptide interactions
Protein-protein interaction networks provide important clues about cell function. However, the picture offered by protein interaction alone is incomplete, because techniques for determining interactions at genome scale lack details as to how they are mediated. Stable protein interactions are thought to be largely mediated by interactions between protein domains while transient interactions occu...
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A major step in the understanding of signal transduction came with the realization that Src homology 2 (SH2) domains bind peptide sequences containing phosphotyro-sine (Pawson and Schlessinger, 1993). Shc is an SH2 domain protein that becomes tyrosine phosphorylated after activation of cells by various cytokines and growth factors. This phosphorylation enables Shc to bind to Grb2, coupling Shc ...
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ژورنال
عنوان ژورنال: Proteome Science
سال: 2012
ISSN: 1477-5956
DOI: 10.1186/1477-5956-10-s1-s9